States
The US maintains a permanent forward military presence in the Gulf (CENTCOM), Iraq, Syria, and Jordan, plus carrier strike groups rotated through the region. It supplies weapons and intelligence to Israel and to Gulf partners (Saudi Arabia, UAE, Bahrain, Qatar, Kuwait), maintains the JCPOA-era and successor sanctions architecture on Iran, and has historically led mediation between Israel and Arab states. US policy on Iran is conducted under sanctions law, executive-order authorities, and standing congressional authorisations.
Strait of Hormuz
Actual closure of the strait would cross a long-standing US red line.
Iranian nuclear weapon
Sustained enrichment to weapons-grade with no inspections is the public red line.
Attacks on US personnel
Successful Iranian or proxy strikes killing US service members trigger declaratory escalation.